Initially thought to be useful only for preventing infectious diseases, it has also found application in prevention of autoimmune diseases, birth control, cancer therapy, etc. Edible vaccines are currently being developed for a number of human and animal diseases. There is growing acceptance of transgenic crops in both industrial and developing countries.
Edible Vaccines Research Papers
Resistance to genetically modified foods may affect the future of edible vaccines. Plants are capable of producing recombinant antigens that undergo similar post translational modifications as their mammalian-derived counterparts and in contrast to bacterial expression systems.
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Skip to main content Skip to main navigation menu Skip to site footer. Keywords: Bacterial expression, Edible vaccines, Transgenic. Abstract Vaccines were the result of trial and error research until molecular biology and genetic engineering made possible the creation of many new and improved vaccines.
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International Journal of Ayurveda and Pharma Research , 3 9. Vol 3, Issue 9: September View Legal Code.
Edible Vaccines: Prophylactic Food
The idea of making edible vaccines has been around since the mids, when tools for genetically modifying plants emerged. But making crops produce proteins that elicit an immune response is easier dreamed of than done: Ingested proteins usually disintegrate in the stomach before they reach the intestine's immune system.
A clever solution is to hurry the vaccine toward its target with the help of the toxin that causes cholera.
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This new strategy was tried by plant molecular biologist William Langridge of Loma Linda University in California and his team. The researchers stitched genes together from three stomach bugs: rotavirus, toxic Escherichia coli , and Vibrio cholerae , which causes cholera. When the researchers served the transgenic potatoes to mice, the animals produced antibodies against all three bacterial and viral proteins. So far so good--but, as Langridge points out, "you can make antibodies against all sorts of antigens, but those antibodies don't necessarily protect the animals" from infections, as has been the case in previous studies with transgenic plant vaccines.
And in those that did get sick, the diarrhea was about half as severe and lasted about half as long as in nonimmunized mice.
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It's another important step forward in the development of plant-based vaccines," says plant biologist Charles Arntzen of Arizona State University in Tempe, who, in , pioneered the production of viral proteins in plants for vaccine purposes. The new study, Arntzen adds, is the most recent in a series of papers that show that plant-based vaccines are "a viable strategy. Langridge's home page Arntzen's home page. By Jeffrey Mervis Oct. By Warren Cornwall Oct. All rights Reserved.